relationship between serum levels of fetuin-a with apo-a1, apo-b100, body composition and insulin resistance in patients with type 2 diabetes
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abstract
background :some results exist on fetuin-a as marker for vascular disease in type 2diabetes. we examined the relationship between serum fetuin-a with some factors, in patients with type 2 diabetes mellitus (t2dm). methods : from october 2012 to june 2013, a total of 131 t2dm patients were recruited and evaluated for various parameters including homa-ir, apo-a1, apo-b100, body fat percentage and waist circumference. serum fetuin-a levels were measured by enzyme-linkedimmunosorbent assay (elisa), and serum glucose with a cobas mira analyzer by enzymatic method. apo-b100 and apo-a1 were measured by immunoturbidimetry with a cobas mira analyzer. homa-ir was calculated by the following formula: [fasting insulin (uiu/ml) × fasting blood glucose (mmol/l)]/22.5. results : the mean levels of homa-ir were significantly increased progressively across fetuin-a tertiles (pfor trend=0.04) in women but not men. fetuin-a had just a significant positive correlation withapo- a1(r=0.22, p=0.02). conclusion : this present study showed that levels of serum fetuin-a are significantly associated with insulin resistance in women with t2dm.
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Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes
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Journal title:
medical journal of islamic republic of iranجلد ۲۸، شماره ۱، صفحات ۶۴۶-۶۵۲
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